Image: MIMS
PhD project within the Industrial Doctoral School at 91´«Ã½ÔÚÏß. The project ended on 25 November 2024 when Ionut Sebastian Mihai defended his doctoral thesis.
Ionut Sebastian Mihai's PhD project focuses on studying the genetic features of T cell activation and differentiation, to then create a computational model that will help pre-clinical and clinical researchers better apply treatments, and deepen the knowledge about our immune system.
Sartorius Stedim Data Analytics 50 %
Industrial Doctoral School 50 %
Johan Trygg, Sartorius Stedim Data Analytics
T-cells are key components of the immune system, and are involved in a vast amount of clinically relevant conditions - from fighting minor pathogenic infections, to directly being involved in complex adaptive immune dynamics that characterize cancers, allergies and autoimmune disorders.
Furthermore, the interaction between T-lymphocytes and other cell types induces a “shaping” effect on the overall fate and role of the naive T cell. Naive T-cells have been isolated from patients' peripheral blood and genetically re-programmed to present a chimeric antigen T cell receptor (CAR T cells), which ultimately leads to enhanced immune defence against cancer. However, to perform this process efficiently, across different ages and sexes, requires an understanding of how T cell activation and associated process are connected. Much effort has already gone into this research.
Ionut Sebastian's research focuses on studying the genetic features of T cell activation and differentiation, to then create a computational model that will help pre-clinical and clinical researchers better apply treatments, and deepen the knowledge about our immune system.
